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KMID : 0870420110150030152
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Korean Journal of Hepato-Biliary-Pancreatic Surgery
2011 Volume.15 No. 3 p.152 ~ p.156
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Treatment outcomes and prognostic factors of gallbladder cancer patients after postoperative radiation therapy
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Kim Su-Zy
Kim Kyu-Bo
Chie Eui-Kyu
Ha Sung-Whan
Kim Sun-Whe
Bang Yung-Jue
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Abstract
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Backgrounds/Aims : To investigate survival rates and prognostic factors of patients with gallbladder cancer who were treated with surgery and postoperative radiation therapy.
Methods: Seventeen gallbladder cancer patients who received surgery and postoperative radiotherapy from October 1989 to April 1998 were included in this retrospective study. Five patients had stage II, 8 patients had stage III, and 4 patients had stage IV disease according to the 1997 American Joint Committee on Cancer (AJCC) staging. All patients received ≥40 Gy of postoperative radiotherapy with a daily dose of 2.0 Gy/fraction and 15 patients received concurrent chemotherapy. An analysis was performed for the endpoints of overall and disease-free survival.
Results: Of the 17 patients, 13 had no residual disease (R0), 1 had microscopic residual disease (R1), and 3 had macroscopic residual disease (R2) after surgery. Among patients with no residual disease, 4 had locoregional recurrences during the follow-up period. One patient with microscopic residual disease had local recurrence. The 5-year overall survival rate was 38.2%. The median overall survival time was 21 months and the median disease-free survival time was 12 months. Old age (≥60 years old), female gender, a high pathological stage (≥IVA), and the presence of residual disease after surgery were significant prognostic factors for disease-free survival.
Conclusions: Despite a high proportion of patients with advanced disease and macroscopic residual disease, the prognosis of gallbladder patients who had postoperative radiotherapy is encouraging. Additional investigation to improve the loco-regional control of gallbladder cancer patients with adverse prognostic factors is warranted.
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KEYWORD
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Gallbladder cancer, Surgery, Radiotherapy, Prognosis
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